From Missouri is a story of a young schoolteacher who comes out West from Missouri, invited by a series of letters from some mysterious Mr. Owen, who says there is an open teacher position in his city. When she arrives, it turns out that "Mr. Owen" was, in fact, a prank: some cowboys thought it was fun to write letters on their boss's typewriter. When Jane Stacey arrives, everyone is shocked to discover not a middle-aged lady but a beautiful young woman. Even after discovering she was lied to, she decides to stay on. Moreover, she has to find who Frank Owens was. Soon young Miss Stacey finds out all the trouble a pretty young woman has to endure when living among cowboys.