"Look Homeward, Angel" is an American coming-of-age story. The novel is considered to be autobiographical and the character of Eugene Gant is generally believed to be a depiction of Thomas Wolfe himself. Set in the fictional town and state of Altamont, Catawba, it covers the span of time from Eugene's birth to the age of 19.
"Of Time and the River" is the continuation of the story of Eugene Gant, detailing his early and mid-twenties. During that time Eugene attends Harvard University, moves to New York City, teaches English at a university there, and travels overseas with his friend Francis Starwick.