In William Dean Howells' 'Oliver Wendell Holmes', a part of his collection 'Literary Friends and Acquaintance', the author delves into the life and work of the renowned American writer and physician, Oliver Wendell Holmes. Howells provides a detailed portrait of Holmes' literary contributions and his impact on the American literary scene during the 19th century. Known for his realism and keen observations of society, Howells' narrative style in this book is rich in detail and offers a unique insight into the personal and professional life of Holmes. The book is a fascinating exploration of the literary context of the time and the intellectual exchanges between prominent figures of the era. Howells' eloquent prose captures the essence of Holmes' literary legacy, making it a compelling read for scholars and enthusiasts of American literature.